Teo Yik Ying            (YY Teo)

Address           : Department of Statistics & Applied Probability
  Blk S16, Level 7
  6 Science Drive
2
  National University of Singapore
  Singapore 117546

 

Telephone      : (65) 6516 2760

Fax                   : (65) 6872 3919

Email               : statyy <AT> nus.edu.sg

 

 
 

 


 

I am currently an Associate Professor with the Saw Swee Hock School of Public Health (SSHSPH) and the Department of Statistics & Applied Probability at the National University of Singapore. I head the Biostatistics Domain in SSHSPH and I am also an Adjunct Visiting Group Leader at the Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR). Currently, I direct the Statistical Genomics Programme at the SSHSPH.

 
 

 

 

 

 

 

 


Research interests

·         Public Health Genomics

·         Integrative Omics

 

Academic records

·         DPhil. in Statistics (2006), University of Oxford, supervisor: Professor Peter Donnelly FRS

·         MSc. (Dist.) in Applied Statistics (2001), University of Oxford, supervisor: Dr Peter Clifford

·         BSc. (1st) in Mathematics (2000), Imperial College

 

Academic appointments

Oct 2011 – current     Head, Biostatistics Domain, Saw Swee Hock School of Public Health, National University of Singapore

                                                Programme Leader, Life Sciences Institute, National University of Singapore

Jan 2010 – current      Associate Professor, joint appointment at Saw Swee Hock School of Public Health and Department of Statistics & Applied Probability, National University of Singapore

Faculty, NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore

Adjunct Visiting Group Leader, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR)

Apr 2010 – Mar 2012 Scientific Member, National Healthcare Group Domain-Specific Review Board, Ministry of Health, Singapore

Jan 2010 – Dec 2012   Member, Programme Management Committee, PhD in Biostatistics, National University of Singapore

Oct 2008 – Dec 2009  Senior Research Fellow, Centre for Molecular Epidemiology, National University of Singapore

Oct 2006 – Dec 2009  Postdoctoral Statistician, Wellcome Trust Centre for Human Genetics, University of Oxford

Associate Lecturer, Department of Statistics, University of Oxford

Visiting Fellow, Department of Statistics & Applied Probability, National University of Singapore

Jun 2005 – Oct 2006   Departmental Lecturer, Department of Statistics, University of Oxford

Jun 2003 – Oct 2006   Teaching Assistant, Department of Statistics & Applied Probability, National University of Singapore

 

Awards and honors

2011                Singapore Youth Award, National Youth Council

2011                Faculty Teaching Excellence Award, National University of Singapore

2010                Young Scientist Award, Singapore National Academy of Science

2010                National Research Foundation Research Fellowship, Singapore

2008                Teaching Excellence Award, University of Oxford

2007                Exceptional Merit Award, Wellcome Trust Centre for Human Genetics, University of Oxford

2006                Teaching Excellence Award, University of Oxford

2004 – 2006    Jesus College Graduate Scholarship, University of Oxford

                        Overseas Research Student Scholarship Award, United Kingdom

2004                Faculty Teaching Excellence Award, Faculty of Science, National University of Singapore

2003 – 2006    Overseas Graduate Scholarship, National University of Singapore

                        Lee Kuan Yew Postgraduate Scholarship, Public Service Commission, Singapore

2000 – 2001    Shell Centenary Scholarship, International Shell Foundation

2000                Sherbrooke Award for Mathematics, University of London

                        Governor’s Prize for Mathematics, Imperial College

1999                                Book Prize for Mathematics, Imperial College

1998                                Letter of Commendation for Mathematics, Imperial College

1997 – 2000    Singapore Government Scholarship, Public Service Commission, Singapore

 

Consortium and committee membership

Jan 2010 – current      Programme Management Committee, PhD in Biostatistics, National University of Singapore

Oct 2007 – current     PI and Analysis Chair, Singapore Genome Variation Project

Oct 2006 – current     Member of Analysis Group, Malaria Genomic Epidemiology Network (MalariaGEN)

Jan 2006 – Jun 2007    Member of Oxford Statistics Group, Wellcome Trust Case Control Consortium

 

Journal editorial board

Nov 2010 – current     Review Editor, Frontiers in Statistical Genetics and Methodology

 

Grants awarded

·         PI: Dr Belinda Kate Cornes

Title: The genetic determinants of age related macular degeneration in Asian populations – a comparative genetic study between three major Asian ethnic groups (Chinese, Indians and Malays) in Singapore
Grant no.: NIG10
Funding agency: National Medical Research Council Singapore
Period: Jul 2010 – Jun 2013
Amount: S$170,288
Role: Mentor to PI of New Investigator Grant

·         PI: Yik Ying Teo
Title: Modeling complex interactions in the genetics and genomics of common phenotypes and infectious diseases
Grant no.:
Funding agency: National Research Foundation Singapore
Period: Jul 2010 – Jun 2013
Amount: US$1,500,000
Role: Principal investigator

·         PI: Prof Tien Yin Wong
Title:
Genetic markers of retinal vascular calibre and cardiovascular disease: The Singapore Malay Eye Study & The Singapore Prospective Study Programme
Grant no.: BMRC 09/1/35/19/616
Funding agency: Biomedical Research Council (BMRC) – Singapore
Co-investigators: E Shyong Tai, Jianjun Liu, Yik Ying Teo
Period: Jan 2010 – Dec 2012
Amount: S$1,122,000
Role: Co-investigator

·         PI: A/Prof Jie Jin Wang
Title: Genetic associations of early retinal pathologic phenotypes: Data pooling and meta-analyses of multiple populations
Chief investigators:
Eric Boerwinkle, Gerald Liew, Pablo Moscato, E Shyong Tai, Alex Hewitt, John Attia, Yik Ying Teo, Ronald Klein, Patrick McElduff
Associate investigators: Tien Yin Wong, Amirul Isalm, Barbara EK Klein, Paul Mitchell, Johannes R Vingerling.
Period: Jan 10 – Dec 12
Amount: A$710,763
Role: Chief investigator

·         Program director: Prof Michael Boehnke                        PI: A/Prof Tai E Shyong
Title: Identifying T2D Variants by DNA Sequencing in Multiethnic Samples
Grant no: U01 DK085584
Funding agency: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Period: Oct 09 - Sept 14
Amount: to be advised
Role: Co-investigator

·         Program director: Prof Mark I McCarthy                        PI: Prof Chia Kee Seng
Title: Identifying variants causal for Type 2 Diabetes in major human populations
Grant no: U01 DK085545.
Funding agency: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Period: Oct 09 - Sept 14
Amount: to be advised
Role: Co-investigator

·         PI: A/Prof Tai E Shyong
Title: Genome-wide case-control studies to identify genetic variants and gene-environment interactions involved in the pathogenesis of type 2 diabetes mellitus in Chinese, Malays and Asian Indians living in Singapore
Co-investigators: Kee-Seng Chia, Woon-Puay Koh, Mark Seielstad, Yik-Ying Teo, Mark Pereira, Daniel O. Stram, Tien-Yin Wong, Su-Chi Lim, Daniel Peng-Keat Ng,
Wern-Ee Tang, Chia-Siong Wong, Myron Gross
Funding agency: NMRC (NMRC/1174/2008)
Period: 23 Jul 08 - Mar 11
Amount: S$1,000,000
Role: Co-investigator

·         PI: Kee-Seng Chia
Title: Singapore Genome Variation Project
Co-PIs: Yik-Ying Teo, Edmund Lee, Mark Seielstad

Funding agency: National University of Singapore

Period: Oct 2007 – Jun 2009

Amount: S$500,000

Role: Co-PI

 

Grants reviewer

·         National Health and Medical Research Council (NHMRC), Australia)

·         Biotechnology and Biomedical Sciences Research Council (BBSRC), UK

·         National Institutes of Health (NIH), National Institute of Allergy and Infectious Diseases (NIAID), USA

·         Swiss National Science Foundation, Switzerland

·         Medical Research Council (MRC), UK

·         Medical Research Council (MRC), UK

·         National Medical Research Council (NMRC), Singapore

Patents

·         DP/3507/Genetics Software Suite – Isis Innovation Limited, Oxford, UK

 

Invited lectures and presentations

2011                Invited lecture, International Conference on Mathematical Biology, Bangalore, India

Invited lecture, Nature Genetics Workshop: GWAS 2011 – Opportunities and Challenges, Anhui, China

Invited lecture, Asia ARVO 2011, Singapore

            2010                Invited lecture, Pharmacogenetics Symposium 2010, Kent Ridge Guild Hall, Singapore

Invited lecture, 19th Korea Genome Organisation Conference, Seoul, South Korea

2009                                Instructor, Wellcome Trust Advanced Course on Genomic Epidemiology of Malaria, Sanger Institute, United Kingdom

Invited lecture, Genetics and Genomics of Infectious Diseases, Singapore

2008                                Invited lecture, Genomic Epidemiology of Malaria, Sanger Institute, United Kingdom

Conference presentation, Genomic Disorders, Sanger Institute, United Kingdom  

Invited lecture, Molecular Medicine and Genomics in Africa, Khartoum, Sudan

2007                Invited lecture, Global enterprise for Micro-Mechanics and Molecular Medicine: Conference on Cancer, Singapore

                        Conference presentation, MalariaGEN 2nd Network Meeting, Sanger Institute, United Kingdom

2006                                Conference presentation, Beyond HapMap, Boston, USA

Conference presentation, Keystone Symposia on Human Genetics, Montana, USA

2005                                Invited lecture, Mathematical Modeling of Infectious Diseases, Singapore

Conference presentation, Genomic Studies and the HapMap, Oxford, United Kingdom

            2003                Accepted talk, Symposium of Stochastics and Applications, Singapore

                       

Selected publications

·         Teo YY, Fry AE, Clark TG, Tai ES, Seielstad M. (2007) On the usage of HWE for identifying genotyping errors. Annals of Human Genetics 71: 701-703. <PubMed>

·         The Wellcome Trust Case-Control Consortium. (2007) Genomewide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447:661-678. <PubMed>

·         Teo YY+, Inouye M+, Small KS, Gwilliam R, Deloukas P, Kwiatkowski DP, Clark TG. (2007) A genotype calling algorithm for the Illumina BeadArray platforms. Bioinformatics 23: 2741-2746. <PubMed>

·         Teo YY, Small KS, Clark TG, Kwiatkowski DP. (2008) Perturbation analysis: a simple method for filtering SNPs with erroneous genotyping in genome-wide association studies. Annals of Human Genetics 72:368-374. <PubMed>

·         Teo YY. (2008) Common statistical issues in genome-wide association studies: a review on power, data quality control, genotype calling and population structure. Current Opinion in Lipidology 19:133-143. <PubMed>

·         Teo YY+, Inouye M+, Small KS, Fry AE, Potter SC, Dunstan SJ, Seielstad M, Barroso, I, Wareham NJ, Rockett KA, Kwiatkowski DP, Deloukas P. (2008) Whole genome amplified DNA: insights and imputation. Nature Methods 5:279-280. <PubMed>

·         Teo YY+, Fry AE+, Pederson B, Small KS, Sanjoaquin MA, Rockett KA, Kwiatkowski DP, Clark TG. (2008) Assessing genuine parents-offspring trios for genetic association studies. Human Heredity 67:26-37. <PubMed>

·         Teo YY, Small KS, Fry AE, Wu Y, Kwiatkowski DP, Clark TG. (2009) Power consequences of linkage disequilibrium variation between populations. Genetic Epidemiology 33:128-135. <PubMed>

·         Jallow M+, Teo YY+, Small KS+, et al. (2009) Genome-wide and fine-resolution association analysis of malaria in West Africa. Nature Genetics [epub 24th May 2009]. <PubMed>

·         Teo YY. (2009) Exploratory data analysis in large-scale genetic studies. Biostatistics [epub 14 Oct 2009]. <PubMed>

·         Teo YY, Small KS. (2009) A novel method for haplotype clustering and visualization. Genetic Epidemiology [epub 28th May 2009]. <PubMed>

·         Holt KE, Teo YY, Li H, Nair S, Dougan G, Wain J, Parkhill J. (2009) Detecting SNPs and estimating allele frequencies in clonal bacterial populations by sequencing pooled DNA samples. Bioinformatics 15:2074-2075. <PubMed>

·         Teo YY, Fry AE, Small KS, Kanishka B, Kwiatkowski DP, Clark TG. (2009) Genome-wide comparisons of variation in linkage disequilibrium. Genome Research 19:1849-1860. <PubMed>

·         Teo YY+, Sim XL+, Ong RTH+, Tan AKS, Chen J, Tantoso E, Small KS, Ku CS, Lee EJD, Seielstad M, Chia KS. (2009) Singapore Genome Variation Project: A haplotype map of three South-East Asian populations. Genome Research 19:2154-2162. <PubMed>

·         Teo YY, Small KS, Kwiatkowski DP. (2010) Methodological challenges of genome-wide association analysis in Africa. Nature Review Genetics 11:149-160. <PubMed>

·         Teo YY, Sim X. (2010) Patterns of linkage disequilibrium in different populations: Implications and opportunities for lipid-associated loci identified from genome-wide association studies. Current Opinion in Lipidology 21:104–115. <PubMed>

·         Tan EK+, Peng R+, Teo YY+, Tan L, Angeles D, Ho P, Chen ML, Lin CH, Mao XY, Prakash KM, Liu JJ, Au WL, Le WD, Jankovic J, Burgunder JM, Zhao Y, Wu RM. (2010) Multiple LRRK2 variants modulate risk of Parkinson’s Disease: a multicenter study in Chinese. Human Mutation 31:561–568. <PubMed>

·         Ong RTH, Teo YY. (2010) varLD: A program for quantifying variation in linkage disequilibrium patterns between populations. Bioinformatics 26:1269–1270. <PubMed>

·         Chen J, Teo YY, Toh DSL, Sung C. (2010) Inter-ethnic comparisons of important pharmacology genes using single nucleotide polymorphism databases: potential application to drug regulatory assessments. Pharmacogenomics 11:1077–1094. <PubMed>

·         Ku CS, Pawitan Y, Sim X, Ong RT, Seielstad M, Lee EJ, Teo YY, Chia KS, Salim A. (2010) Genomic copy number variations in three Southeast Asian populations. Human Mutation 31:851–857. <PubMed>

·         Teo YY, Ong RTH, Sim X, Tai ES, Chia KS. (2010) Identifying candidate causal variants via trans-population fine-mapping. Genetic Epidemiology [epub 13th Sep] <PubMed>

 

+ Joint first authors

 

            Full publication list can be found here.

            Updated CV can be found here.